天然药物系

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朱清

作者:金飞     日期:2023-11-06   点击数:2695  

师资介绍



姓名:朱清

性别:男

出生年月:1978.08

学历:医学博士

职称:教授;博士生导师(特种医学研究院)

职务:天然药物与药物分析系主任

邮箱:zhuqing@ntu.edu.cn

 

研究方向:

天然镇痛药物研发;药物动力学以及代谢组学研究

 

学术兼职:

Frontiers in Pharmacology评审编辑

教育部学位中心硕士研究生论文盲审专家

多种SCI杂志审稿人

科研项目:

1. 国家自然科学基金面上项目,82071238,基于疼痛抑制行为探讨去甲青藤碱靶向α2-GABAA受体的镇痛效应,2021/01-2024/1255万,在研,主持(PI

2. 江苏省自然科学基金面上项目,BK20181459,基于疼痛抑制行为的去甲青藤碱镇痛效应及与GABAA受体相关机制研究,2018/07-2021/0610万,结题,主持(PI

3. 江苏省自然科学青年基金项目,BK20181459,益母草碱抗心肌缺血作用及药效物质基础的代谢组学研究,2013/07-2016/0620万,结题,主持(PI

4. 国家自然科学基金面上项目,81971243TAAR1-CaMKII-CREB信号通路调节尼古丁成瘾,2020/01-2023/1255万,在研,副主持(Co-PI

5. 国家自然科学基金面上项目,81373390,选择性咪唑啉I2受体配体的镇痛效应及滥用潜力研究,2014/01-2017/1265万元,结题,副主持(Co-PI

6. 中国博士后自然科学基金面上项目,2016M591898, 基于疼痛抑制行为的青藤碱及其代谢物镇痛作用研究2016/05-2019/055万元,结题,主持(PI

代表性论文:

1. Lulu Yu, Xunjia Qian, Yiheng Feng, Yujian Yin, Xiao-Dan Zhang, Qianqian Wei, Liyun Wang, Weiwei Rong, Jie-Jia Li, Jun-Xu Li*, Qing Zhu*. Investigation of preclinical pharmacokinetics of N-demethylsinomenine, a potential novel analgesic candidate, using an UPLC-MS/MS quantification method. Front Chem. 2023, 11:1222560. doi: 10.3389/fchem.2023.1222560. (通讯作者)

2. Huixiao Duo*, Jiayuan Yue, Yujian Yin, Xiaoyu Xu, Liyun Wang, Lulu Yu, Xunjia Qian, Jiejia Li, Qing Zhu*.Magnetic carbon nanoparticles derived from Co-based metal-organic frameworks for magnetic solid-phase extraction and determination of phenylurea herbicides. Microchem. J., 2023, 185:108190.(通讯作者)

3. Weiwei Rong, Jiejia Li, Dingyi Pan, Qinbei Zhou, Yexuan Zhang, Qianxing Lu, Liyun Wang, Andong Wang, Yizhun Zhu*, Qing Zhu*. Cardioprotective Mechanism of Leonurine against Myocardial Ischemia through a Liver–Cardiac Crosstalk Metabolomics Study. Biomolecules, 2022, 12, 1512. (通讯作者)

4. Feifeng Yang, Yue Zhu, Congyu Zhang, Ziyan Yang, Jia Yuan, Qing Zhu*, Shushu Ding*. A highly sensitive and selective artificial nanochannel for in situ detection of hydroxyl radicals in single living cell. Anal. Chim. Acta., 2022 1235:340537(通讯作者)

5. Weiwei Rong, Jiejia Li, Lifeng Wang, Shanshan Luo, Tulu Liang, Xunjia Qian, Xiaodan Zhang, Qinbei Zhou, Yizhun Zhu*, Qing Zhu*. Investigation of the protective mechanism of leonurine against acute myocardial ischemia by an integrated metabolomics and network pharmacology strategy. Front. Cardiovasc. Med., 2022, 9: 969553.(通讯作者)

6. Ming-Cong Zheng, Wen-Ting Tang, Lu-Lu Yu, Xun-Jia Qian, Jie Ren, Jie-Jia Li, Wei-Wei Rong, Jun-Xu Li and Qing Zhu*. Preclinical Pharmacokinetics and Bioavailability of Oxypeucedanin in Rats after Single Intravenous and Oral Administration. Molecules, 2022, 27, 3570.(通讯作者)

7. Xiaohua Pan#, Qing Zhu#, Li-Long Pan*, Jia Sun*. Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy. Pharmacol. & Ther., 2022238: 108176. (共同第一作者)

8. Zhiyong Zhou, Nanqing Qiu, Yuntao Ou, QianqianWei, WentingTang, Mingcong Zheng, Yaluan Xing, Jie‑Jia Li, Yong Ling, Junxu Li* & Qing Zhu*. NDemethylsinomenine, an active metabolite of sinomenine, attenuates chronic neuropathic and infammatory pain in mice. Sci. Rep., 2021, 11:9300.  (通讯作者)

9. Yuntao Ou, Man Su, Yong Ling, Qianqian Wei, Fei Pan, Jiejia Li, Jun-Xu Li*, Qing Zhu*. Anti-allodynic effects of N-demethylsinomenine, an active metabolite of sinomenine, in a mouse model of postoperative pain. Eur. J. Pharmacol. 2018, 823:105–109. (通讯作者)

10. Yong Ling, Jing Guo, Qiuxing Yang, Peng Zhu, Jiefei Miao, Weijie Gao, Yanfu Peng, Jiaying Yang, Kun Xu, Biao Xiong, Gongqing Liu, Jinhua Tao, Lin Luo, Qing Zhu*, Yanan Zhang*. Development of novel β-carboline-based hydroxamate derivatives as HDAC inhibitors with antiproliferative and antimetastatic activities in human cancer cells. Eur. J. Med. Chem., 2018, 144:398-409. (通讯作者)

11. Qing Zhu, Yuehua Sun, Lina Mao, Chengpeng Liu, Bo Jiang, Wei Zhang & Jun-Xu Li. Antinociceptive effects of sinomenine in a rat model of postoperative painBrit. J. Pharmacol., 2016, 173:1693-1702.

12. Qing Zhu, Li-Na Mao, Cheng-Peng Liu, Yue-Hua Sun, Bo Jiang, Wei Zhang & Jun-Xu Li. Antinociceptive effects of vitexin in a mouse model of postoperative pain. Sci. Rep., 2016, 6:19266.

13. Qing Zhu, Yuehua Sun, Jie Zhu, Tian Fang, Wei Zhang & Jun-Xu Li. Antinociceptive effects of sinomenine in a rat model of neuropathic pain. Sci. Rep., 2014, 4: 7270.

14. Qing Zhu, Yuehua Sun, Xiaodi Yun, Yuntao Ou, Wei Zhang & Jun-Xu Li. Antinociceptive effects of curcumin in a rat model of postoperative pain, Sci. Rep., 2014, 4:4932.

15. Qing Zhu, Jinlian Zhang, Ping Yang, Bo Tan, Xinhua Liu, Yuanting Zheng, Weimin Cai & Yizhun Zhu. Characterization of Metabolites of Leonurine (SCM-198) in Rats after Oral Administration by Liquid Chromatography/Tandem Mass Spectrometry and NMR Spectrometry, Sci. World J., 2014, 2014:947946.

16.  Qing Zhu, Weimin Cai, Xianyi Sha, Guo Ma, Yuanting Zheng, Xueru Shi & Yizhun Zhu. Quantification of leonurine, a novel potential cardiovascular agent, in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in rats, Biomed. Chromatogr., 2012, 26(4): 518-523.

17. Jie-Jia Li#, Qing Zhu#, Ya-Peng Lu, Peng Zhao, Zhan-Bo Feng, Zhong-Ming Qian & Li Zhu. Ligustilide prevents cognitive impairment and attenuates neurotoxicity in D-galactose induced aging mice brain, Brain Res., 2015,1595:19-28. (共同第一作者)

18. Donggeng Wang#, Qing Zhu #, Baohua Liu, Guangtong Chen & Yong Ling. Identification of gut microbial metabolites of a synthetic nitric oxide-releasing farnesylthiosalicylic acid derivative, an antitumor agent, Anal. Lett., 2014, 47(2):191-201.(共同第一作者)

19. Qing Zhu, Jinhua Gu, Hongyan Zhu & Jiliang Xu. Identification of differentially expressed genes in dorsal root ganglion in early diabetic rats, Neurosci. Bull., 2008, 24(4):219-24.  

授权发明专利

1. Zhu, Qing, et al. anlagesic drug composition. 2020/12/18, NigeriaNG/PT/C/2020/4763.  

2. 朱清,李俊旭,苏漫,李洁佳,欧云淘,一种镇痛药物组合物,2021/03/19

中国,ZL201710671939.4  

3. 朱清,卫蒨蒨,唐文婷,李俊旭,潘菲,邱男青,周致用,李洁佳,氧化前胡素的新用途,2020/05/08,中国ZL201810813028.5

4. 朱清,李俊旭,卫蒨蒨,潘菲,邱男青,李洁佳,氧化前胡素在制备治疗术后疼痛药物中的应用,2020/04/28,中国ZL201810751676.2

5. 朱清,李俊旭,孙越华,青藤碱在制备治疗慢性疼痛伴抑郁行为药物中的应用,2017/01/04,中国,ZL201410456667.2

6. 李俊旭,朱清,欧云淘,苏漫,赵颖,去甲青藤碱在制备镇痛药物中的应用,2019/12/20 中国,ZL201610331233.9

7. 李俊旭,朱清,毛丽娜,刘成鹏,孙越华,牡荆素在制备治疗术后疼痛中的应用,2017.11.07,中国,ZL201510642790.8

 

获奖情况:

2023年荣获南通市药学会优秀学术带头人奖;

2022年海燕策略百家论坛“互联网+”大学生创业大赛二等奖(指导教师)

2015年获南通市科学技术进步奖二等奖(排名第四);

2011年获海燕策略百家论坛2011届毕业设计(论文)优秀指导教师